Ultrafast Confocal Raman Imaging

Ultrafast superresolution fluorescence imaging with spinning disk confocal microscope optics

Most current superresolution (SR) microscope techniques surpass the diffraction limit at the expense of temporal resolution, compromising their applications to live-cell imaging. Here we describe a new SR fluorescence microscope based on confocal microscope optics, which we name the spinning disk superresolution microscope (SDSRM). Theoretically, the SDSRM is equivalent to a structured illumina...

Complementary Stxm and Confocal Raman Imaging of Murchison

Introduction: Scanning transmission X-ray mi-croscopy (STXM) and confocal Raman imaging have been utilized on a sample of the Murchison CM2 meteorite in order to examine the structure and composition of carbonaceous material with a minimal degree of alteration due to sample preparation. The resulting complementary data set shows minute variation in car-bonaceous material crystallinity proximal ...

A handheld laser scanning confocal reflectance imaging–confocal Raman microspectroscopy system

Confocal reflectance microscopy and confocal Raman spectroscopy have shown potential for non-destructive analysis of samples at micron-scale resolutions. Current studies utilizing these techniques often employ large bench-top microscopes, and are not suited for use outside of laboratory settings. We have developed a microscope which combines laser scanning confocal reflectance imaging and confo...

Ultrafast second-Stokes diamond Raman laser.

We report a synchronously-pumped femtosecond diamond Raman laser operating with a tunable second-Stokes output. Pumped using a mode-locked Ti:sapphire laser at 840-910 nm with a duration of 165 fs, the second-Stokes wavelength was tuneable from 1082 - 1200 nm with sub-picosecond duration. Our results demonstrate potential for cascaded Raman conversion to extend the wavelength coverage of standa...

Confocal Raman Microscopy in Pharmaceutical Development